Theodoridou-Christodoulides-2021

Authors: Daniela Theodoridou, Pavlos Christodoulides, Victoria Zakopoulou. andMaria Syrrou.

Article: Developmental Dyslexia: Environment Matters.

Publication: Brain Sciences (MDPI). 11(6), 782 | DOI: https://doi.org/10.3390/brainsci11060782

[Full Text]

Developmental dyslexia (DD) is a multifactorial, specific learning disorder. Susceptibility genes have been identified, but there is growing evidence that environmental factors, and especially stress, may act as triggering factors that determine an individual’s risk of developing DD. In DD, as in most complex phenotypes, the presence of a genetic mutation fails to explain the broad phenotypic spectrum observed. Early life stress has been repeatedly associated with the risk of multifactorial disorders, due to its effects on chromatin regulation, gene expression, HPA axis function and its long-term effects on the systemic stress response. Based on recent evidence, we discuss the potential role of stress on DD occurrence, its putative epigenetic effects on the HPA axis of affected individuals, as well as the necessity of early and appropriate intervention, based on the individual stress-associated (endo)phenotype.

Tagged as: environmental, epigenetics, and stress

Citation:

Theodoridou, D., Christodoulides, P., Zakopoulou, V., & Syrrou, M. (2021). Developmental Dyslexia: Environment Matters. Brain Sciences, 11(6), 782. MDPI AG. Retrieved from http://dx.doi.org/10.3390/brainsci11060782

Leave a public question or comment:

If you need personal help or assistance please use our contact forms instead.


All comments are moderated. Comments that are not relevant to the page topic or which contain identifiable personal information will not be published.


Your email address will not be published. Required fields are marked *